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Big Data and Biological Networks · Quiz 2 · Jan 2024

Big Data and Biological Networks · Quiz 2 · Jan 2024

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0 / 21 published solutions

Question 2 MCQ · 1.0 marks

How many solutions are possible for a string reconstruction problem with 12 words?
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Question 3 MCQ · 1.0 marks

What is the number of 4-mers generated from the sequence : “AGATATATTATTGTCTTTTTTGTCA”?
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20
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22
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15
6406532563718.
21

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Question 4 MCQ · 2.0 marks

What is the average degree (regardless of the direction) of the 3-mer overlap graph constructed from “ATGATACT”?
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4.1
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2.4
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3.4
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2

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Question 5 MCQ · 2.0 marks

What is the total number of edges of the De-Bruijn Graph generated from the 3-mers obtained from “ATGATCTAAATATCAAG”?
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15
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14
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16
6406532563726.
17

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Question 6 MCQ · 2.0 marks

In a directed protein-protein interaction network, the researchers want to identify protein clusters that interact densely with each other but have sparse connections to other proteins in the network. Which method would be the most effective in discovering these hubs?
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Using betweenness centrality.
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Using the degree distribution.
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Using Girvan-Newman algorithm.
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Finding nodes with high in-degree but low out-degree.

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Question 7 MCQ · 2.0 marks

Which of the following statements is true regarding motif identification in networks?
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Motifs are patterns found in random networks
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Motifs are exclusively found in biological networks and are absent in other types of networks.
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Motif identification involves detecting recurring and significant subgraph patterns in a network.
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Motifs are only relevant in small networks and have no significance in larger- scale networks.

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Question 8 MCQ · 2.0 marks

Consider the gene interaction networks given below for 4 different conditions (2 normal and 2 diseased).
Source diagram or notation
Which of the following can be observed from the networks shown?
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A-E is a housekeeping interaction
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E-B is a housekeeping interaction
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A-D is a differential interaction between normal and disease networks
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E-D is a differential interaction between normal and disease networks

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Question 9 MCQ · 2.0 marks

Investigator X is tasked with identifying the spread of a virus in a city. The team has narrowed down the origin of the spread to 4 locations and obtained the contact tracing information for 4 suspected individuals. The social contact network is represented as a bipartite graph. Answer the following questions based on the provided network.
Source diagram or notation
Find the projection of the location contact network at 11:00. Note: No transition time is considered for traveling between locations.
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Question 10 MCQ · 2.0 marks

Source diagram or notation
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(i)-A, (ii) - B, (iii) -C
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(i)-B, (ii) - A, (iii) -C
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(i)-C, (ii) - A, (iii) -B
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(i)-C, (ii) - B, (iii) -A

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Question 11 MCQ · 3.0 marks

What is the total number of nodes of the De-Bruijn Graph generated from the 2-mers obtained from “TACTCTAAG”?
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3
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5
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6
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4

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Question 12 MCQ · 3.0 marks

Given the two sequences “AGAGCTTA”, “AAGAGTTGA”, and the scoring paradigm: matches: “+2”, mismatches: “-3” and gap: “-1”, find the final score for the best global alignment between the two sequences.
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10
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11
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2
6406532563734.
8

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Question 13 MCQ · 3.0 marks

Given the k-mers : ’GCCGT’, ’CGTAG’, ’TAGGC’, ’GTAGG’, ’CTATG’, ’CCGTA’, ’TATGC’, ’TGCCG’, ’AGGCG’, ’ATGCC’, reconstruct the sequence from which the k-mers were generated.
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CTATACCGTAGGCG
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CTATGCCGTAGGCG
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ATCGGTACAACGG
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TATGCCGTAGGCGC

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Question 14 MSQ · 2.0 marks

We have a graph that was constructed by comparing n DNA sequences. If the two sequences can be aligned with a score greater than a threshold value, we assign an edge between the two in the graph. Given this, which of the following is true:
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Inserting a new node to the graph requires n comparisons
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Inserting a new node is a node level task
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If all the alignments have the same score, the resultant graph is a complete graph
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There will be two connected components in the resultant graph

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Question 15 MSQ · 2.0 marks

Which of the following makes an appropriate pair?
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Node classification – Predicting drug-drug interaction
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Graph classification – Predicting toxicity of a chemical compound
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Link Prediction – Predicting function of novel proteins
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Graph regression – Predicting free energy of hydration

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Question 16 MSQ · 3.0 marks

Which of these are challenges one might encounter in the process of genome assembly?
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Erroneous reads
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Large volumes of data
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Duplicate sequences
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Incomplete graph

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Question 17 MSQ · 3.0 marks

Consider the following two statements: Statement 1: Reads from the genome sequencing are prone to error. Statement 2: Sequence alignment can be used to overcome this problem. Based on your observations, which of the following statements is not true?
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Both statements are true and statement 2 is a potential solution for statement 1
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Both statements are true but statement 2 is not a solution to statement 1
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Both statements are false
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Statement 1 is false but Statement 2 is true

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Question 18 MSQ · 3.0 marks

Source diagram or notation
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Question 19 MSQ · 3.0 marks

Source diagram or notation
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Question 20 MCQ · 3.0 marks

Use the following metabolic network to answer the given questions.
Source diagram or notation
What is the dimension of the stoichiometric matrix of the provided network?
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4×4
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5×5
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4×5
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5×4

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Question 21 MCQ · 3.0 marks

Use the following metabolic network to answer the given questions.
Source diagram or notationSource diagram or notation
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R1 - R2
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b1 + b2 - R2
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b1 + b2 - b3
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R2 - R1

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Question 22 MCQ · 3.0 marks

Use the following metabolic network to answer the given questions.
Source diagram or notation
What is the stoichiometric matrix of the provided network? Note: The order of reactions is (R1, R2, b1, b2, b3)
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      **SW Engg** **Section Id :** 64065353055 **Section Number :** 2 **Section type :** Online **Mandatory or Optional :** Mandatory **Number of Questions :** 22

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